Buserelin

Buserelin is a synthetic hormone used primarily in the treatment of hormone-sensitive cancers such as prostate cancer and breast cancer. It is a type of gonadotropin-releasing hormone agonist (GnRH agonist) that works by decreasing the production of certain hormones in the body.

Medical uses

Buserelin is used in the treatment of prostate cancer, breast cancer, and in some cases, for the management of endometriosis and uterine fibroids. It is also used in assisted reproduction to control ovulation.

Mechanism of action

Buserelin acts by initially stimulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. However, with continuous administration, it desensitizes the pituitary gland, leading to a decrease in the production of LH and FSH. This results in a reduction of testosterone and estrogen levels in the body, which is beneficial in treating hormone-sensitive cancers.

Administration

Buserelin can be administered via subcutaneous injection, intramuscular injection, or as a nasal spray. The route of administration depends on the condition being treated and the specific needs of the patient.

Side effects

Common side effects of buserelin include hot flashes, sweating, headaches, and mood changes. Long-term use can lead to a decrease in bone density, increasing the risk of osteoporosis.

See also

• Gonadotropin-releasing hormone
• Prostate cancer
• Breast cancer
• Endometriosis
• Uterine fibroids
• Assisted reproduction

References

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