File:Hemoglobinopathies-Slicing-the-Gordian-Knot-of-Plasmodium-falciparum-Malaria-Pathogenesis-ppat.1003327.g001.jpg

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	23:08, 20 October 2014		759 × 686 (170 KB)	Recitation-bot	Automatic upload of media from: doi:10.1371/journal.ppat.1003327

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Image title	General mechanisms by which hemoglobinopathies may attenuate the pathogenesis of falciparum malaria.(A) Restriction of red blood cell (RBC) invasion or intraerythrocytic growth, thereby suppressing parasite densities in vivo; (B) interference with parasite-derived mediators of pathogenesis, including those involved in the binding of parasite-infected RBCs (iRBCs) to extracellular host receptors; (C) modulation of innate host defenses to favor protective, anti-inflammatory responses over those that drive pathogenic, pro-inflammatory responses; (D) enhancement of adaptive cell-mediated and humoral immune responses that clear iRBCs from the blood.
Copyright holder	Public Domain
Date(s)	16 May 2013
Publisher	Public Library of Science
Short title	Figure 1
Source	info:doi/10.1371/journal.ppat.1003327
Identifier	info:doi/info:doi/10.1371/journal.ppat.1003327.g001
IIM version	2