2,5-Dimethoxy-4-bromobenzylpiperazine

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2,5-Dimethoxy-4-bromobenzylpiperazine (2C-B-BZP) is a psychoactive drug and a substituted piperazine that has been sold as a designer drug. It combines structural features of the phenethylamine 2C-B and the drug BZP. The effects of 2C-B-BZP are believed to be similar to those of 2C-B, including hallucinogenic effects, due to its structural similarity. However, the addition of a benzylpiperazine group may alter its pharmacological properties significantly, making it more similar to other piperazine derivatives in terms of effects, which can include stimulation and euphoria.

Chemistry[edit | edit source]

2,5-Dimethoxy-4-bromobenzylpiperazine is a chemical compound that belongs to the class of substituted piperazines. The molecule consists of a benzylpiperazine moiety linked to a 2C-B-like structure. The presence of methoxy groups at the 2 and 5 positions of the benzene ring, and a bromine atom at the 4 position, are characteristic of the 2C family of psychedelic compounds, which are known for their hallucinogenic and entactogenic effects.

Pharmacology[edit | edit source]

The pharmacological action of 2C-B-BZP is not well understood, but it is believed to act primarily as a serotonin receptor agonist, similar to other compounds in the 2C family. This action at serotonin receptors can lead to altered perception, mood, and consciousness. The addition of the benzylpiperazine group may also confer stimulant properties to the compound, potentially through action on the dopamine and norepinephrine systems, similar to other BZP derivatives.

Effects[edit | edit source]

Users of 2C-B-BZP may experience a range of effects, including visual and auditory hallucinations, increased energy, euphoria, altered perception of time, and increased empathy and sociability. However, the effects can vary greatly between individuals, depending on a variety of factors including dose, individual sensitivity, and the presence of other substances.

Risks and Safety[edit | edit source]

As with many designer drugs, the safety profile of 2C-B-BZP is not well established. Potential risks include psychological dependence, neurotoxicity, and acute adverse reactions such as panic attacks, hypertension, and severe hallucinations. The lack of research and regulation surrounding these substances makes them particularly risky, as the purity and dosage can vary significantly between batches.

Legal Status[edit | edit source]

The legal status of 2C-B-BZP varies by country, with some jurisdictions having specific legislation controlling its sale, possession, and use, while in others it may fall under general controlled substance or analogue laws. The rapidly evolving nature of designer drug markets makes it difficult to keep legislation up to date with the emergence of new compounds like 2C-B-BZP.

See Also[edit | edit source]

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Contributors: Prab R. Tumpati, MD