3-hydroxyphencyclidine

3-Hydroxyphencyclidine (3-HO-PCP) is a dissociative hallucinogen that is related to phencyclidine (PCP). It is a potent NMDA receptor antagonist with a distinctive set of effects that set it apart from other dissociatives.

Chemistry

3-Hydroxyphencyclidine is a member of the aryl cyclohexylamine class. It is structurally related to phencyclidine (PCP) and more specifically, is a single hydroxy group derivative of PCP. The name 3-Hydroxyphencyclidine refers to the position of the hydroxy group on the phenyl ring.

Pharmacology

As an NMDA receptor antagonist, 3-HO-PCP inhibits the action of the NMDA receptor, a specific subtype of the glutamate receptor. This results in a decrease in the overall level of neuronal excitability, leading to the drug's dissociative effects.

Effects

The effects of 3-HO-PCP can vary greatly depending on the dose and individual's physiology. Common effects include dissociation, hallucination, and euphoria. At higher doses, it can cause delirium, amnesia, and psychosis.

Risks

Like other NMDA receptor antagonists, 3-HO-PCP has the potential for serious side effects. These can include psychosis, neurotoxicity, and addiction. It is also possible to experience a bad trip or overdose on 3-HO-PCP.

Legal Status

The legal status of 3-HO-PCP varies by country. In some countries, it is a controlled substance, while in others it is legal to possess for personal use.

See Also

• Phencyclidine
• Dissociative
• Hallucinogen
• NMDA receptor antagonist

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