6β-Hydroxycortisol
6β-Hydroxycortisol
6β-Hydroxycortisol is a metabolite of cortisol formed in the liver by the enzyme 6β-hydroxysteroid dehydrogenase. It plays a crucial role in the regulation of cortisol levels in the body.
Metabolism[edit | edit source]
Upon secretion by the adrenal glands, cortisol undergoes metabolism in the liver, where it is converted to 6β-hydroxycortisol by the enzyme 6β-hydroxysteroid dehydrogenase. This metabolic pathway is essential for the regulation of cortisol levels and maintaining homeostasis in the body.
Function[edit | edit source]
6β-Hydroxycortisol serves as a marker for the activity of the enzyme 6β-hydroxysteroid dehydrogenase. Changes in the levels of 6β-hydroxycortisol can indicate alterations in cortisol metabolism and may be associated with various conditions such as Cushing's syndrome or adrenal insufficiency.
Clinical Significance[edit | edit source]
Abnormal levels of 6β-hydroxycortisol have been linked to certain endocrine disorders, making it a valuable biomarker in the diagnosis and monitoring of such conditions. Measurement of 6β-hydroxycortisol levels in urine or blood samples can provide insights into adrenal function and aid in the management of adrenal disorders.
References[edit | edit source]
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