8-Cyclopentyl-1,3-dipropylxanthine

8-Cyclopentyl-1,3-dipropylxanthine (also known as 8-CPT or DPCPX) is a potent and selective antagonist of the adenosine A1 receptor. It is used in scientific research to understand the role of this receptor in the body.

Chemistry

8-Cyclopentyl-1,3-dipropylxanthine is a xanthine derivative. Xanthines are a class of compounds that are structurally similar to purines, which are key components of nucleic acids like DNA and RNA. The 8-cyclopentyl and 1,3-dipropyl substitutions on the xanthine backbone of 8-CPT give it its unique pharmacological properties.

Pharmacology

8-Cyclopentyl-1,3-dipropylxanthine acts as an antagonist at the adenosine A1 receptor. This means it binds to this receptor but does not activate it, instead blocking the effects of the natural agonist, adenosine. The adenosine A1 receptor is one of four known types of adenosine receptors in the body, the others being the A2A, A2B, and A3 receptors. 8-CPT is selective for the A1 receptor, meaning it has much greater affinity for this receptor than for the other types.

Uses in Research

Because of its potent and selective antagonism of the adenosine A1 receptor, 8-Cyclopentyl-1,3-dipropylxanthine is used in scientific research to study the role of this receptor in the body. It has been used in studies investigating the role of the adenosine A1 receptor in conditions such as cardiovascular disease, neurological disorders, and sleep disorders.

Safety and Toxicity

As a research chemical, 8-Cyclopentyl-1,3-dipropylxanthine is not intended for human consumption. Its safety and toxicity in humans have not been thoroughly studied.

See Also

• Adenosine receptor
• Xanthine
• Purine
• Antagonist (pharmacology)