9,11-Dehydrocortexolone 17α-butyrate
9,11-Dehydrocortexolone 17α-butyrate is a synthetic corticosteroid and a derivative of cortexolone. It is primarily used in the treatment of various skin conditions due to its potent anti-inflammatory properties.
Chemical Structure and Properties[edit | edit source]
9,11-Dehydrocortexolone 17α-butyrate is a steroid with a specific chemical structure that includes a butyrate ester at the 17α position. This modification enhances its lipophilicity, allowing for better skin penetration and prolonged action.
Mechanism of Action[edit | edit source]
As a corticosteroid, 9,11-Dehydrocortexolone 17α-butyrate works by binding to glucocorticoid receptors in the skin. This binding inhibits the release of pro-inflammatory cytokines and mediators, reducing inflammation, itching, and redness associated with various dermatological conditions.
Clinical Uses[edit | edit source]
9,11-Dehydrocortexolone 17α-butyrate is used in the management of:
- Eczema
- Psoriasis
- Dermatitis
- Other inflammatory skin disorders
Side Effects[edit | edit source]
Common side effects of 9,11-Dehydrocortexolone 17α-butyrate include:
Dosage and Administration[edit | edit source]
The dosage and administration of 9,11-Dehydrocortexolone 17α-butyrate depend on the severity of the condition being treated. It is typically applied topically to the affected area once or twice daily.
Precautions[edit | edit source]
Patients using 9,11-Dehydrocortexolone 17α-butyrate should be monitored for signs of adrenal suppression, especially if used over large surface areas or for prolonged periods.
See Also[edit | edit source]
References[edit | edit source]
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