Acoramidis
Synonyms[edit source]
Acoramidis, ACORAMIDIS, AG 10, AG-10, AG10, TTR Stabilizer AG10, Transthyretin Stabilizer AG10
Thesaurus
A potent, highly selective, orally bioavailable transthyretin (TTR) stabilizer with potential disease-modifying activity. Upon oral administration, acoramidis binds to and stabilizes transthyretin (TTR), thereby preventing tetramer dissociation into monomers. This prevents misfolding of the TTR protein and inhibits the formation of TTR amyloid fibrils and the subsequent deposition of these insoluble protein clusters in the heart and peripheral nerves. TTR is a 127 amino acid transport protein for thyroxine and retinol and is secreted by the liver into the blood. The accumulation of TTR amyloid fibrils may result in thickening and stiffening of the ventricular wall, leading to heart failure. Acoramidis, Pharmacologic Substance
- NCI Thesaurus (external)
C87006. This concise article on Acoramidis incorporates public domain text from the US National Library of Medicine.
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