Adp-ribosyltransferase 5

ADP-ribosyltransferase 5 (ART5) is an enzyme that in humans is encoded by the ART5 gene. This enzyme belongs to the family of transferases, specifically those transferring glycosyl groups. The systematic name of this enzyme class is ADP-ribose:D-arginine ADP-ribosyltransferase. Other names in common use include ADP-ribosyltransferase 5, and ADP-ribosyltransferase, arginine-specific, 5.

Function

The ART5 enzyme is involved in the ADP-ribosylation process, a reaction that transfers the ADP-ribose moiety of NAD+ to an acceptor molecule, which can be a protein, peptide, or small molecule. This process is important in various biological functions, including DNA repair, gene regulation, and apoptosis.

Structure

The ART5 enzyme is a monomeric protein that consists of a catalytic domain and a regulatory domain. The catalytic domain is responsible for the transfer of the ADP-ribose moiety, while the regulatory domain controls the activity of the enzyme.

Clinical significance

Mutations in the ART5 gene have been associated with various diseases, including cancer and neurodegenerative disorders. The enzyme's role in DNA repair and apoptosis makes it a potential target for therapeutic interventions.

See also

• ADP-ribosylation
• Transferase
• Gene
• Enzyme

References

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