Ajmaline
Ajmaline is a class Ia antiarrhythmic agent often used in the diagnosis of Brugada syndrome, a rare genetic disorder that can cause heart rhythm problems. It is an alkaloid that is found in the plants of the Apocynaceae family, particularly those in the Rauwolfia genus.
History[edit | edit source]
Ajmaline was first isolated in 1931 by Salimuzzaman Siddiqui, a Pakistani organic chemist. He named it after Hakim Ajmal Khan, one of the most illustrious practitioners of Unani medicine in South Asia.
Medical Uses[edit | edit source]
Ajmaline is used in the diagnosis of Brugada syndrome, a condition that results in a disruption of the heart's normal rhythm. This is done through an ajmaline challenge, where the drug is administered and the patient's ECG is monitored for changes.
Pharmacology[edit | edit source]
Ajmaline works by blocking the fast inward sodium current (INa). It slows the conduction velocity and increases the duration of the action potential.
Side Effects[edit | edit source]
Common side effects of ajmaline include nausea, vomiting, and diarrhea. More serious side effects can include heart block, arrhythmias, and hypotension.
See Also[edit | edit source]
References[edit | edit source]
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