Allylnorpethidine

WIN-7681

Allylnorpethidine is a synthetic opioid analgesic that is structurally related to pethidine (also known as meperidine). It is part of the 4-phenylpiperidine class of opioids and has been studied for its potential use in pain management.

Chemical Structure and Properties

Allylnorpethidine is chemically known as 4-phenyl-1-(2-propenyl)-4-piperidinecarboxylic acid ethyl ester. It is a derivative of pethidine, where the N-methyl group is replaced by an allyl group. This modification alters its pharmacological properties compared to pethidine.

Pharmacology

As an opioid, allylnorpethidine acts primarily on the mu-opioid receptors in the central nervous system to produce analgesia. Its efficacy and potency in comparison to other opioids like morphine and pethidine have been subjects of research. The presence of the allyl group may influence its binding affinity and metabolic stability.

Medical Use

Allylnorpethidine has been investigated for its potential use in the treatment of moderate to severe pain. However, its clinical use is limited, and it is not as widely used as other opioids such as morphine or fentanyl. The side effect profile, including the risk of opioid addiction and respiratory depression, is a significant consideration in its medical application.

Side Effects

The side effects of allylnorpethidine are similar to those of other opioids and may include:

• Nausea
• Vomiting
• Constipation
• Drowsiness
• Respiratory depression
• Addiction

Legal Status

The legal status of allylnorpethidine varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and addiction.

See Also

• Opioid
• Pethidine
• Analgesic
• Mu-opioid receptor
• Opioid addiction

References

‎