Benzamil
Benzamil is a potent diuretic and sodium channel blocker. It is primarily used in the research of kidney function and heart failure. It is derived from amiloride.
Pharmacology[edit | edit source]
Benzamil blocks epithelial sodium channels (ENaCs) in the kidney, lung, and sweat glands. It also inhibits the activity of sodium-hydrogen antiporters, particularly those in the renal tubules. This leads to decreased sodium reabsorption and increased potassium retention.
Medical Uses[edit | edit source]
Benzamil is used in research to study the effects of sodium channel blocking in the treatment of conditions such as hypertension, heart failure, and cystic fibrosis. It is also used to study the role of ENaCs in kidney function and fluid balance.
Side Effects[edit | edit source]
Potential side effects of benzamil include hyperkalemia, dehydration, and metabolic acidosis. These are due to its effects on sodium and potassium balance in the body.
See Also[edit | edit source]
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