Benzoylecgonine

Benzoylecgonine-2D-skeletal

Benzoylecgonine is a major metabolite of cocaine, a stimulant drug extracted from the leaves of the coca plant. It is primarily used as a marker in the drug testing industry to detect the presence of cocaine use. Benzoylecgonine is detectable in urine, blood, and hair samples through various analytical methods, including gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS).

Chemical Structure and Properties

Benzoylecgonine has a chemical formula of C₁₆H₁₉NO₄. It is formed in the liver by the hydrolysis of cocaine, facilitated by the enzyme esterase. The process removes the methyl ester group from cocaine, resulting in the formation of benzoylecgonine, which is less lipophilic than cocaine and more easily excreted in the urine.

Pharmacokinetics

Following the administration of cocaine, benzoylecgonine can be detected in the blood within a few hours, and its presence can be noted for a significantly longer period than cocaine itself, often up to several days after the last use, depending on the individual's metabolism, the quantity of cocaine used, and the frequency of use. This extended detection window makes benzoylecgonine a reliable marker for cocaine use in drug testing.

Detection in Drug Testing

Drug tests for cocaine use typically screen for the presence of benzoylecgonine due to its longer half-life compared to cocaine. The detection threshold for benzoylecgonine in urine drug tests is commonly set at 150 ng/mL to 300 ng/mL to minimize the chance of false positives from passive exposure to cocaine. Advanced analytical techniques, such as GC-MS and LC-MS, are employed to ensure the accuracy and reliability of the test results.

Legal and Forensic Relevance

The detection of benzoylecgonine in biological samples has significant legal and forensic implications, especially in cases involving drug use, driving under the influence of drugs, and workplace drug testing. The presence of benzoylecgonine can be used as evidence of recent cocaine use, which may have legal consequences depending on the laws of the jurisdiction.

Health Implications

While benzoylecgonine itself is not psychoactive, its presence in the body indicates exposure to cocaine, which has various health risks, including the potential for addiction, cardiovascular issues, and neurological effects. The detection of benzoylecgonine in drug tests can serve as a basis for medical intervention and support for individuals struggling with cocaine dependence.

Benzoylecgonine Resources
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