Beta-Thromboglobulin

Beta-Thromboglobulin (also known as β-Thromboglobulin or β-TG) is a protein that is released from platelets during platelet activation. It is a member of the CXC chemokine family and is also known as Platelet factor 4 variant 1 (PF4V1).

Structure

Beta-Thromboglobulin is a small cytokine belonging to the CXC chemokine family. It is approximately 7.8 kilodaltons in size and is composed of 70 amino acid residues. The protein has a four-stranded antiparallel beta-sheet conformation.

Function

Beta-Thromboglobulin is stored in the alpha-granules of platelets and is released upon platelet activation. It plays a role in inflammation and wound healing by promoting neutrophil recruitment and angiogenesis. It also has chemotactic properties, attracting monocytes and lymphocytes to the site of injury.

Clinical significance

Levels of Beta-Thromboglobulin in the blood can be measured as a marker of platelet activation. Elevated levels of Beta-Thromboglobulin have been associated with various thrombotic conditions, including myocardial infarction, stroke, and deep vein thrombosis. It may also be elevated in conditions associated with increased platelet turnover, such as immune thrombocytopenic purpura and myeloproliferative disorders.

See also

• Platelet factor 4
• Chemokine
• Platelet activation

References

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