CDC14B

Protein CDC14B PDB 1ohc

Cell division cycle 14B
Identifiers
Symbol	CDC14B
Alt. symbols	-
NCBI gene	8556
OMIM	603196
RefSeq	NM_003675
UniProt	Q96EK5
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Cell division cycle 14B (CDC14B) is a protein-coding gene involved in cell cycle regulation. It plays a crucial role in the control of cell division and cell cycle progression. CDC14B is a member of the CDC14 phosphatase family, which is known for its phosphatase activity in cell cycle regulation.

Function

CDC14B functions as a dual-specificity phosphatase, meaning it can dephosphorylate both phosphotyrosine and phosphoserine/threonine residues on its substrate proteins. This dephosphorylation activity allows CDC14B to regulate key cell cycle events, such as mitotic exit and cytokinesis. By dephosphorylating specific target proteins, CDC14B helps coordinate the orderly progression of the cell cycle.

Structure

The CDC14B protein consists of several conserved domains, including a phosphatase domain responsible for its enzymatic activity. It also contains regulatory domains that control its subcellular localization and activity during different phases of the cell cycle. The structure of CDC14B allows it to interact with various binding partners and substrates to carry out its functions in cell cycle regulation.

Regulation

The activity of CDC14B is tightly regulated to ensure proper cell cycle progression. It is subject to post-translational modifications, such as phosphorylation and ubiquitination, which can affect its stability and activity. Additionally, CDC14B localization within the cell is dynamically regulated, with changes in localization playing a role in its function during different stages of the cell cycle.

Role in Disease

Mutations or dysregulation of CDC14B have been associated with various diseases, including cancer. Aberrant expression of CDC14B can disrupt normal cell cycle control, leading to uncontrolled cell proliferation and tumor formation. Understanding the role of CDC14B in disease pathogenesis may provide insights for developing targeted therapies for conditions involving cell cycle dysregulation.