CPEB

CPEB Proteins

Cytoplasmic Polyadenylation Element Binding Protein (CPEB)

Cytoplasmic Polyadenylation Element Binding Protein (CPEB) is a crucial regulatory protein involved in the post-transcriptional control of gene expression. CPEB plays a significant role in the regulation of mRNA translation and stability in eukaryotic cells.

Function

CPEB functions by binding to specific sequences known as cytoplasmic polyadenylation elements (CPEs) located in the 3' untranslated region (UTR) of target mRNAs. Upon binding to CPEs, CPEB can modulate the polyadenylation of the mRNA, leading to changes in translation efficiency and mRNA stability.

Role in Synaptic Plasticity

In neurons, CPEB has been extensively studied for its role in synaptic plasticity, particularly in the process of long-term potentiation (LTP). CPEB is involved in the local protein synthesis at synapses, which is essential for the establishment and maintenance of synaptic connections.

Regulation

The activity of CPEB is tightly regulated by various signaling pathways and post-translational modifications. Phosphorylation of CPEB, for example, can modulate its binding affinity to target mRNAs and influence its function in translational control.

Clinical Implications

Dysregulation of CPEB has been associated with various neurological disorders, including Alzheimer's disease and fragile X syndrome. Understanding the mechanisms underlying CPEB dysfunction may provide insights into the pathophysiology of these conditions and potential therapeutic targets.

See also

• mRNA
• Translation (biology)
• Synaptic plasticity