Calciphylaxis

Calciphylaxis, also known as calcific uremic arteriolopathy, is a rare and serious disease characterized by the calcification of small blood vessels within the dermis and subcutaneous tissue. This condition leads to the development of painful skin ulcers and can result in necrosis.

Symptoms

The primary symptoms of calciphylaxis include:

• Painful skin ulcers
• Areas of necrosis
• Erythema and induration around the affected areas

Complications

Calciphylaxis can lead to severe complications such as:

• Sepsis
• Organ failure

Causes

The exact cause of calciphylaxis is not fully understood, but it is commonly associated with:

• Chronic kidney disease (CKD)
• Hyperparathyroidism
• Diabetes mellitus

Risk Factors

Several risk factors have been identified for calciphylaxis, including:

• End-stage renal disease (ESRD)
• Obesity
• Female gender

Diagnosis

Diagnosis of calciphylaxis is typically made through:

• Clinical evaluation
• Skin biopsy

Differential Diagnosis

Conditions that may present similarly and should be considered include:

• Warfarin-induced skin necrosis
• Cholesterol embolism

Treatment

Treatment options for calciphylaxis focus on managing symptoms and may include:

• Sodium thiosulfate
• Wound care
• Pain management

Prognosis

The prognosis for calciphylaxis is generally poor, with a high risk of mortality due to complications such as sepsis and organ failure.

See also

• Chronic kidney disease
• Hyperparathyroidism
• Diabetes mellitus
• End-stage renal disease

References

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