Carbon monoxide-releasing molecules

Carbon monoxide-releasing molecules (CORMs) are a group of chemical compounds that release carbon monoxide (CO) in a controlled manner. They are a subject of research due to their potential therapeutic applications, particularly in the field of pharmacology and medicine.

Overview

CORMs are designed to deliver carbon monoxide to biological systems. Carbon monoxide, a gaseous molecule, has been recognized for its potential therapeutic effects, including anti-inflammatory, anti-apoptotic, and anti-proliferative activities. However, due to its toxic nature, direct administration of CO is not feasible. CORMs, therefore, provide a safer and more effective way to deliver CO.

Types of CORMs

There are several types of CORMs, classified based on their chemical structure and CO release mechanism. These include:

• Metal carbonyls: These are the most extensively studied CORMs. Examples include CORM-2 (ruthenium carbonyl) and CORM-3 (tricarbonylchloro(glycinato)ruthenium(II)).
• Boron-based CORMs: These are non-metal based CORMs that release CO upon reaction with a specific trigger, such as light or a particular enzyme.
• PhotoCORMs: These CORMs release CO upon exposure to light.

Therapeutic Applications

CORMs have potential therapeutic applications in various medical conditions, including:

• Cardiovascular diseases: CORMs have been shown to reduce myocardial infarction size and improve heart function in animal models.
• Inflammatory diseases: CORMs exhibit anti-inflammatory effects and may be beneficial in conditions such as rheumatoid arthritis and inflammatory bowel disease.
• Cancer: CORMs have anti-proliferative effects and may inhibit tumor growth.

Safety and Toxicity

While CORMs provide a safer way to deliver CO, their safety and toxicity profile is still a subject of research. Factors such as the rate of CO release, the stability of the CORM, and the presence of other toxic by-products can influence their safety and efficacy.

See Also

• Carbon monoxide
• Pharmacology
• Medicine