Cefmatilen

Cefmatilen is a cephalosporin antibiotic used to treat a variety of bacterial infections. It belongs to the third generation of cephalosporins and is known for its broad-spectrum activity against both Gram-positive and Gram-negative bacteria.

Mechanism of Action

Cefmatilen works by inhibiting the synthesis of the bacterial cell wall. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which inhibits the final transpeptidation step of peptidoglycan synthesis. This action results in the weakening of the bacterial cell wall and ultimately leads to cell lysis and death.

Pharmacokinetics

Cefmatilen is administered orally and is well-absorbed from the gastrointestinal tract. It is distributed widely throughout the body, including the cerebrospinal fluid (CSF), which makes it effective in treating central nervous system infections. The drug is primarily excreted unchanged in the urine.

Clinical Uses

Cefmatilen is used to treat a variety of infections, including:

• Respiratory tract infections
• Urinary tract infections
• Skin and soft tissue infections
• Bone and joint infections
• Intra-abdominal infections

Side Effects

Common side effects of cefmatilen include:

• Nausea
• Diarrhea
• Rash
• Headache

Serious side effects may include:

• Anaphylaxis
• Stevens-Johnson syndrome
• Clostridioides difficile infection

Contraindications

Cefmatilen is contraindicated in patients with a known hypersensitivity to cephalosporins or any component of the formulation. Caution is advised in patients with a history of penicillin allergy due to potential cross-reactivity.

Drug Interactions

Cefmatilen may interact with other medications, including:

• Aminoglycosides: Increased risk of nephrotoxicity
• Probenecid: Increases the concentration of cefmatilen in the blood

See Also

• Cephalosporin
• Antibiotic resistance
• Bacterial infection

External Links

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