Charles Mantoux

Charles Mantoux (1877–1947) was a French physician best known for developing the Mantoux test, a diagnostic tool for tuberculosis. The Mantoux test, also known as the Mantoux screening test, tuberculin sensitivity test, or PPD test for purified protein derivative, is a method of determining whether a person has been infected with the Mycobacterium tuberculosis bacteria.

Early Life and Education[edit | edit source]

Charles Mantoux was born in France in 1877. He pursued his medical education in France, where he was deeply influenced by the prevailing challenges in diagnosing and treating infectious diseases, notably tuberculosis, which was a leading cause of death at the time.

Career[edit | edit source]

After completing his medical studies, Mantoux dedicated himself to research in infectious diseases, with a particular focus on tuberculosis. His work was inspired by earlier developments in tuberculin testing, notably by Robert Koch and Clemens von Pirquet. Koch had discovered tuberculin, while Pirquet developed the concept of a skin test for tuberculosis. Mantoux sought to improve the reliability and accuracy of tuberculin testing, which led him to develop the intradermal injection method.

The Mantoux test involves injecting a small amount of tuberculin into the skin of the forearm and observing the reaction 48 to 72 hours later. A positive reaction, typically a swelling at the injection site, indicates that the person has been exposed to the tuberculosis bacteria and has developed an immune response. However, the test does not distinguish between latent infection and active disease.

Legacy[edit | edit source]

Charles Mantoux's contribution to the field of medicine and public health is significant. The Mantoux test remains a cornerstone in the diagnosis and management of tuberculosis worldwide. Despite the development of newer diagnostic tools, the Mantoux test continues to be widely used due to its simplicity, low cost, and effectiveness in identifying individuals who have been infected with tuberculosis.

Mantoux's work has also paved the way for further research in immunological testing and the management of infectious diseases. His dedication to improving public health has saved countless lives and continues to influence medical practices today.

Death[edit | edit source]

Charles Mantoux passed away in 1947, leaving behind a legacy that continues to impact the field of medicine, particularly in the diagnosis and treatment of tuberculosis.