DHSA

DHSA or Dehydroepiandrosterone sulfate is a steroid hormone produced by the adrenal gland. It is the most abundant circulating steroid in humans and plays a key role in a range of bodily functions.

Production and Function

DHSA is produced in the adrenal cortex, the outer layer of the adrenal gland. It is synthesized from cholesterol through a series of enzymatic reactions. The final step in the production of DHSA is the sulfation of dehydroepiandrosterone (DHEA) by the enzyme sulfotransferase.

DHSA serves as a precursor for the production of sex hormones, including estrogen and testosterone. It also has a number of other functions in the body, including the regulation of immune system function, bone density, and body composition.

Clinical Significance

Abnormal levels of DHSA can be indicative of a number of medical conditions. High levels of DHSA can be associated with polycystic ovary syndrome (PCOS), while low levels can be indicative of Addison's disease or hypopituitarism.

DHSA is also used in the treatment of a number of conditions, including systemic lupus erythematosus (SLE), osteoporosis, and depression. However, the use of DHSA supplements is controversial due to potential side effects and the lack of long-term safety data.

See Also

• Adrenal gland
• Steroid hormone
• Dehydroepiandrosterone
• Polycystic ovary syndrome
• Addison's disease

References

DHSA Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.