Doravirine/lamivudine/tenofovir disoproxil
Doravirine/lamivudine/tenofovir disoproxil is a fixed-dose combination of antiretroviral medications used in the treatment of HIV/AIDS. It contains three active ingredients: doravirine, lamivudine, and tenofovir disoproxil. This combination is marketed under the brand name Delstrigo by Merck.
Composition[edit | edit source]
The combination drug contains three active ingredients:
- Doravirine: A non-nucleoside reverse transcriptase inhibitor (NNRTI) that prevents the HIV virus from replicating in the body.
- Lamivudine: A nucleoside reverse transcriptase inhibitor (NRTI) that works by interfering with the normal functioning of the HIV virus.
- Tenofovir disoproxil: Another NRTI that helps to decrease the amount of HIV in the body, thereby helping the immune system to work better.
Usage[edit | edit source]
Doravirine/lamivudine/tenofovir disoproxil is used in the treatment of HIV-1 infection in adults. It is used in combination with other antiretroviral agents. The drug is taken orally, once daily, with or without food.
Side Effects[edit | edit source]
Common side effects of Doravirine/lamivudine/tenofovir disoproxil include nausea, diarrhea, headache, fatigue, and abdominal pain. Serious side effects may include lactic acidosis, severe hepatomegaly with steatosis, and post treatment acute exacerbation of hepatitis B.
Precautions[edit | edit source]
Before starting treatment with Doravirine/lamivudine/tenofovir disoproxil, patients should be tested for hepatitis B virus infection. Patients with renal impairment, hepatic impairment, or who are co-infected with hepatitis B or C should be monitored closely during treatment.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD