EPH receptor B1

Protein EPHB1 PDB 2djs

EPH receptor B1

EPH receptor B1 is a protein that in humans is encoded by the EPHB1 gene. It belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. This gene is a member of the Eph receptor family of receptor tyrosine kinases. The encoded protein is highly similar to the protein encoded by the EPHA1 gene.

Function

The protein encoded by this gene is a receptor for members of the ephrin-A family. It binds to ephrin-A1, -A3, -A4, and -A5. The ephrin receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.

Clinical significance

Mutations in this gene have been associated with neurodevelopmental disorders, including autism spectrum disorders.

Interactions

EPH receptor B1 has been shown to interact with:

• EFNA1,
• EFNA3,
• EFNA4, and
• EFNA5.

See also

• EPH receptor
• EPH receptor A1