Fat storage-inducing transmembrane protein 1

Fat storage-inducing transmembrane protein 1 (FITM1) is a protein that in humans is encoded by the FITM1 gene. It is a member of the Fat storage-inducing transmembrane (FITM) protein family, which is involved in the storage of triglycerides in adipocytes and hepatocytes.

Function

FITM1 is involved in the formation of lipid droplets, which are specialized organelles for the storage of neutral lipids, particularly triglycerides. These droplets play a crucial role in energy homeostasis and lipid metabolism. FITM1 is thought to facilitate the partitioning of triglycerides into the lipid droplets, thereby promoting fat storage.

Clinical significance

Alterations in the function or expression of FITM1 may contribute to metabolic disorders such as obesity and type 2 diabetes. Studies have shown that overexpression of FITM1 in mice leads to increased fat storage and obesity, while knockdown of FITM1 reduces fat storage.

Research

Research into the function and regulation of FITM1 may provide insights into the mechanisms of fat storage and the development of obesity and related metabolic disorders. This could potentially lead to the development of new therapeutic strategies for these conditions.

See also

• Fat storage-inducing transmembrane protein 2
• Lipid droplet
• Obesity
• Type 2 diabetes

References

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