Fluticasone

Fluticasone

Fluticasone is a synthetic corticosteroid medication used primarily as an inhaled corticosteroid in the treatment of asthma and chronic obstructive pulmonary disease (COPD). It works by reducing inflammation in the airways, making it easier for individuals to breathe.

History[edit | edit source]

Fluticasone was first approved for medical use in the United States in 1990. Since then, it has become a widely prescribed medication for the management of asthma and COPD.

Mechanism of Action[edit | edit source]

Fluticasone exerts its anti-inflammatory effects by binding to glucocorticoid receptors, leading to the activation of anti-inflammatory genes and the suppression of pro-inflammatory genes. This results in reduced inflammation in the airways, leading to improved respiratory function.

Indications[edit | edit source]

Fluticasone is indicated for the maintenance treatment of asthma as a prophylactic therapy. It is also used in the management of COPD to reduce exacerbations and improve lung function.

Side Effects[edit | edit source]

Common side effects of fluticasone include sore throat, hoarseness, and thrush in the mouth. Long-term use of high doses may also lead to systemic side effects such as adrenal suppression and osteoporosis.

Precautions[edit | edit source]

Patients using fluticasone should be monitored for signs of adrenal insufficiency, particularly during times of stress. It is important to rinse the mouth after each use to reduce the risk of oral thrush.

Interactions[edit | edit source]

Fluticasone may interact with certain medications, such as ritonavir and ketoconazole, leading to increased systemic exposure to fluticasone. Patients should inform their healthcare provider of all medications they are taking before starting fluticasone therapy.