GABRP

GABRP or Gamma-aminobutyric acid receptor subunit pi is a protein that in humans is encoded by the GABRP gene. It is a member of the GABA receptor family, which are integral membrane proteins that respond to the neurotransmitter gamma-aminobutyric acid (GABA).

Function

GABRP is a subunit of the GABA-A receptor, which is a pentameric ligand-gated ion channel. This receptor is the primary inhibitory neurotransmitter receptor in the brain. The GABRP subunit is expressed in several non-neuronal tissues including the uterus, where it may be involved in uterine contractility.

Structure

The GABRP protein is composed of four transmembrane domains with both the N- and C-terminus located extracellularly. The protein forms a pentameric channel that is permeable to chloride ions when activated by GABA.

Clinical significance

Alterations in GABRP expression have been associated with several disorders including epilepsy, schizophrenia, and alcohol dependence. In particular, increased expression of GABRP has been observed in the brains of individuals with alcohol dependence, suggesting a potential role in the development of this disorder.

Research

Research into GABRP has focused on its role in various neurological and psychiatric disorders. In addition, its expression in non-neuronal tissues suggests it may have roles outside of the nervous system that are yet to be fully understood.

See also

• GABA receptor
• Gamma-aminobutyric acid
• Neurotransmitter

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