GSDMB

GSDMB (Gasdermin B) is a protein that in humans is encoded by the GSDMB gene. It is a member of the gasdermin family, which is known for its role in cell death processes, particularly pyroptosis.

Function

GSDMB is a protein that is part of the gasdermin family. These proteins are characterized by their ability to form pores in the cell membrane, leading to cell death. GSDMB is thought to play a role in inflammation and immune response.

Clinical significance

Alterations in the GSDMB gene have been associated with susceptibility to asthma and autoimmune diseases. In particular, a variant of the GSDMB gene has been linked to a higher risk of developing childhood-onset asthma.

Research

Research into GSDMB is ongoing, with studies investigating its role in various diseases and conditions. For example, some studies are looking at how GSDMB might be involved in the development of certain types of cancer, such as breast cancer and colorectal cancer.

See also

• Gasdermin
• Pyroptosis
• Asthma
• Autoimmune disease

References

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