Galactose 1-dehydrogenase (NADP+)

Galactose 1-dehydrogenase (NADP+) is an enzyme that catalyzes the chemical reaction of converting D-galactose into D-galactono-1,4-lactone. This reaction is dependent on the coenzyme nicotinamide adenine dinucleotide phosphate (NADP+). The systematic name of this enzyme class is D-galactose:NADP+ 1-oxidoreductase.

Function

Galactose 1-dehydrogenase (NADP+) plays a crucial role in the metabolism of galactose, a type of sugar that is less sweet than glucose. It is involved in the Leloir pathway, which is the primary pathway for the metabolism of galactose in the body. This pathway converts galactose into glucose, which can then be used for energy production.

Structure

Like other enzymes, Galactose 1-dehydrogenase (NADP+) is a protein that is made up of amino acids. The exact structure of this enzyme can vary depending on the species in which it is found. However, it typically consists of a single polypeptide chain.

Clinical Significance

Deficiencies in Galactose 1-dehydrogenase (NADP+) can lead to galactosemia, a rare genetic metabolic disorder that affects an individual's ability to metabolize galactose. This can result in a buildup of galactose in the blood, leading to various symptoms such as jaundice, vomiting, and failure to thrive. If left untreated, galactosemia can lead to serious complications such as liver disease, kidney failure, and mental retardation.

See Also

• Galactose
• Enzyme
• Metabolism
• Galactosemia
• Leloir pathway

References

‎