HLA-DRB3
HLA-DRB3 is a gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-DRB3 is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.
Function[edit | edit source]
The HLA-DRB3 gene belongs to the HLA class II, DR beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).
Clinical significance[edit | edit source]
The HLA-DRB3 gene is associated with a susceptibility to diseases such as rheumatoid arthritis, systemic lupus erythematosus, and Sjögren's syndrome.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD