Interleukin-31

Interleukin-31 (IL-31) is a protein that in humans is encoded by the IL31 gene. IL-31 is a member of the gp130/IL-6 cytokine family. The interleukin 31 receptor is a heterodimer composed of Interleukin-31 receptor A and Oncostatin M receptor.

Function

IL-31 is a cytokine that influences cell proliferation, survival, and apoptosis. It is involved in several cellular activities including cell proliferation, cell differentiation, and cell migration. IL-31 is associated with the pathogenesis of inflammation and itching, and it may function in skin immunity.

Clinical significance

IL-31 has been linked to a variety of diseases, including atopic dermatitis, pruritus, and inflammatory bowel disease. It is also implicated in other diseases, such as lymphoma.

Structure

The structure of IL-31 is similar to that of other members of the gp130/IL-6 cytokine family. It is a four-helix bundle protein.

External links

• IL31 Gene at GeneCards

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