Irreversible enzyme inhibitor
Irreversible enzyme inhibitors are a type of enzyme inhibitor that binds to enzymes in a permanent manner, often with covalent bonds. They are different from reversible inhibitors, which bind to enzymes temporarily.
Mechanism of Action[edit | edit source]
Irreversible inhibitors work by permanently binding to an enzyme, which prevents the enzyme from functioning. This is often achieved through the formation of a covalent bond with the enzyme, which is a strong type of chemical bond that is not easily broken. This means that the enzyme is permanently deactivated and can no longer catalyze reactions.
Types of Irreversible Inhibitors[edit | edit source]
There are several types of irreversible inhibitors, including:
- Active site-directed inhibitors: These inhibitors bind to the active site of the enzyme, which is the region of the enzyme where the substrate binds and the reaction takes place.
- Suicide inhibitors (also known as mechanism-based inhibitors): These inhibitors bind to the enzyme and are initially processed by the enzyme as if they were a substrate. However, during this process, the inhibitor is converted into a reactive form that covalently binds to the enzyme, permanently deactivating it.
Examples of Irreversible Inhibitors[edit | edit source]
Some examples of irreversible inhibitors include:
- Aspirin: Aspirin irreversibly inhibits the enzyme cyclooxygenase, which is involved in the production of prostaglandins and thromboxanes.
- Penicillin: Penicillin irreversibly inhibits the enzyme transpeptidase, which is involved in the synthesis of bacterial cell walls.
Clinical Significance[edit | edit source]
Irreversible inhibitors have important clinical applications. They are often used as drugs to treat various diseases. For example, aspirin is used as an anti-inflammatory and antithrombotic drug, while penicillin is used as an antibiotic.
See Also[edit | edit source]
Irreversible enzyme inhibitor Resources | ||
---|---|---|
|
|
Translate to: East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD