Kulchitsky cell

Kulchitsky cells are a type of neuroendocrine cell found in the respiratory tract and the digestive system. Named after the Russian histologist Vladimir Kulchitsky, these cells play a crucial role in the secretion of various hormones and neurotransmitters.

Function

Kulchitsky cells are primarily responsible for the production and release of serotonin, a neurotransmitter that regulates mood, appetite, and sleep. They also produce other hormones such as substance P and calcitonin gene-related peptide (CGRP), which are involved in pain transmission and inflammation.

Location

Kulchitsky cells are found in the lining of the respiratory tract, particularly in the bronchus and trachea. They are also present in the digestive system, specifically in the stomach, small intestine, and large intestine.

Clinical Significance

Abnormal growth of Kulchitsky cells can lead to a type of cancer known as Kulchitsky cell carcinoma or small cell lung cancer. This is a highly aggressive form of cancer that often spreads to other parts of the body before it is diagnosed.

See Also

• Neuroendocrine tumor
• Carcinoid syndrome
• Neuroendocrine system

References

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