LGR6

LGR6 (Leucine-rich repeat-containing G-protein coupled receptor 6) is a protein that in humans is encoded by the LGR6 gene. It is a member of the rhodopsin-like family of G protein-coupled receptors (GPCRs) and is known to play a crucial role in stem cell biology.

Function

The LGR6 protein is a marker of stem cell populations in the skin, mammary glands, and other organs. It is involved in the Wnt signaling pathway, a group of signal transduction pathways made of proteins that pass signals into a cell through cell surface receptors. This pathway plays a critical role in the regulation of cell fate, proliferation, migration, and polarity.

Clinical significance

Mutations in the LGR6 gene have been associated with a variety of diseases, including certain types of cancer. For example, overexpression of LGR6 has been observed in colorectal cancer and is associated with poor prognosis. It is also implicated in skin cancer and breast cancer.

Research

Research into the LGR6 gene and its associated protein may provide insights into the development of novel therapeutic strategies for treating diseases such as cancer. For example, targeting the LGR6 protein could potentially inhibit the growth of cancer cells.

See also

• Leucine-rich repeat
• G protein-coupled receptor
• Stem cell
• Wnt signaling pathway
• Cancer

References

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