LTN1

LTN1 is a gene that in humans is encoded by the LTN1 protein. This protein is a part of the ribosome quality control complex (RQC) which plays a crucial role in maintaining the health and functionality of cells.

Function

The protein encoded by the LTN1 gene is a E3 ubiquitin-protein ligase Listerin. This protein is involved in the degradation of stalled ribosomes in the process known as Ribosome-associated Quality Control (RQC). When a ribosome stalls during protein synthesis, LTN1 is responsible for ubiquitinating the unfinished protein, marking it for degradation and preventing the accumulation of potentially harmful, misfolded proteins.

Clinical significance

Mutations in the LTN1 gene have been associated with neurodegenerative diseases. For example, a mutation in the LTN1 gene has been linked to a familial form of Amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord.

Research

Research into the LTN1 gene and its associated protein continues to be a significant area of study in the field of molecular biology and genetics. Understanding the function and mechanisms of the LTN1 gene may provide insights into the development of neurodegenerative diseases and potential therapeutic strategies.

See also

• Ubiquitin-protein ligase
• Ribosome-associated Quality Control
• Amyotrophic lateral sclerosis

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