LY 215840

LY 215840 is a chemical compound that is often used in biomedical research. It is a potent and selective serotonin 5-HT2A receptor antagonist. This compound has been used in various studies to understand the role of 5-HT2A receptors in the brain and their potential implications in various neurological disorders.

Chemical Structure[edit | edit source]

LY 215840 is a dihydrobenzofuran derivative. Its chemical structure is characterized by a dihydrobenzofuran core, which is substituted at the 5-position with a phenyl group. The phenyl group is further substituted at the 4-position with a piperazine ring. The piperazine ring is substituted at one of its nitrogen atoms with a propyl chain.

Pharmacology[edit | edit source]

LY 215840 acts as a potent and selective antagonist at the 5-HT2A receptor. The 5-HT2A receptor is one of the several different subtypes of the 5-HT2 receptor that are found in the central nervous system. These receptors are involved in a variety of physiological functions, including the regulation of mood and cognition, as well as the modulation of the immune system.

Clinical Implications[edit | edit source]

The selective antagonism of the 5-HT2A receptor by LY 215840 has potential implications in the treatment of various neurological disorders. For instance, the 5-HT2A receptor has been implicated in the pathophysiology of schizophrenia, and LY 215840 may therefore have potential as an antipsychotic drug. Similarly, the 5-HT2A receptor is also involved in the regulation of mood and anxiety, suggesting that LY 215840 may have potential in the treatment of mood disorders and anxiety disorders.

Research Use[edit | edit source]

LY 215840 is widely used in biomedical research to study the role of the 5-HT2A receptor in the brain. It is often used in animal models to induce a state of 5-HT2A receptor antagonism, allowing researchers to investigate the effects of this state on various physiological and behavioral parameters.