Laban sign

Risa hontiveros

Laban sign is a clinical sign used in the diagnosis of peripheral neuropathy, specifically in relation to Charcot-Marie-Tooth disease (CMT), a genetic disorder that affects the peripheral nerves. It is named after the physician who first described it. The Laban sign is characterized by the inability to oppose or bring together the little finger and thumb, indicating weakness or atrophy of the intrinsic hand muscles, which are often affected in the early stages of CMT.

Detection and Clinical Relevance

The detection of the Laban sign involves a simple clinical examination where the patient is asked to perform the thumb and little finger opposition. Failure to do so, or difficulty in performing this action, may suggest the presence of peripheral neuropathy. This sign is particularly relevant in the early diagnosis of Charcot-Marie-Tooth disease, where early detection can significantly influence management and prognosis.

Pathophysiology

The pathophysiology behind the Laban sign lies in the degeneration or dysfunction of the peripheral nerves that innervate the muscles of the hand, particularly those responsible for the opposition of the thumb and little finger. In Charcot-Marie-Tooth disease, this is typically due to mutations in genes responsible for the structure and function of the peripheral nerves, leading to progressive muscle weakness and atrophy.

Diagnostic Importance

While the Laban sign is not exclusive to Charcot-Marie-Tooth disease, its presence in a patient with a compatible clinical history and other neurological findings can strongly suggest CMT. It is often used in conjunction with other clinical signs and diagnostic tests, such as nerve conduction studies and genetic testing, to confirm the diagnosis.

Treatment and Management

There is no cure for Charcot-Marie-Tooth disease, but the identification of the Laban sign and early diagnosis of CMT can allow for interventions that may help manage symptoms and improve quality of life. Management strategies may include physical therapy, occupational therapy, use of orthotic devices, and, in some cases, surgery to correct deformities or improve function.

Conclusion

The Laban sign is a valuable clinical tool in the diagnosis of peripheral neuropathy, particularly in the early detection of Charcot-Marie-Tooth disease. Its simplicity and non-invasiveness make it an accessible option for initial screening, underscoring the importance of thorough clinical examination in the diagnostic process.

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