Leflutrozole

Leflutrozole

Leflutrozole appears to be a typographical error or a non-standard term, as there is no widely recognized medication or substance by this name in medical or scientific literature as of my last update. It's possible that the intended term might be "Letrozole," a well-known medication used in certain breast cancer treatments and fertility issues. Given this, I will proceed to create a detailed entry based on "Letrozole," assuming that was the intended subject. If "Leflutrozole" is a specific topic with information available after my last update, the following content would not apply.

Letrozole

Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor used in the treatment of hormonally-responsive breast cancer after surgery. It has also been used in the treatment of endometriosis and is employed in fertility treatments for women with ovulation problems. Letrozole is taken by mouth.

Medical Uses

Letrozole is primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. It has shown to be effective in significantly reducing the risk of cancer recurrence. Additionally, it is used off-label for ovulation induction to treat infertility in women with polycystic ovary syndrome (PCOS) or other ovulatory disorders.

Mechanism of Action

Letrozole works by inhibiting the enzyme aromatase, which is involved in the production of estrogens in the body. By decreasing estrogen levels, letrozole can slow or stop the growth of hormone-sensitive tumors.

Side Effects

Common side effects of letrozole include hot flashes, joint pain, fatigue, and increased risk of osteoporosis. It is contraindicated in women who are pregnant or breastfeeding due to potential harm to the fetus or infant.

Pharmacology

Letrozole is a nonsteroidal inhibitor of aromatase which effectively lowers estrogen levels in postmenopausal women, leading to a reduction in the size and growth rate of certain types of breast tumors that require estrogen to grow.

History

Letrozole was approved for medical use in the United States in 1997 and is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.

See Also

• Aromatase inhibitor
• Breast cancer
• Endometriosis
• Polycystic ovary syndrome

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