Levosulpiride

Levosulpiride is a prokinetic agent and antipsychotic medication that is used primarily in the treatment of gastroesophageal reflux disease (GERD), irritable bowel syndrome (IBS), and psychosis. It is a selective antagonist of the dopamine D2 receptor.

Etymology

The term "Levosulpiride" is derived from its chemical name, which is (S)-(-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide.

Pharmacology

Levosulpiride acts by blocking the activity of the dopamine D2 receptors. This action results in an increase in the release of acetylcholine, a neurotransmitter that stimulates the muscles of the gastrointestinal tract, thereby improving motility and relieving symptoms of GERD and IBS.

Uses

Levosulpiride is used in the treatment of:

• Gastroesophageal reflux disease (GERD)
• Irritable bowel syndrome (IBS)
• Psychosis

Side Effects

Common side effects of Levosulpiride include:

• Nausea
• Vomiting
• Diarrhea
• Dry mouth
• Weight gain
• Insomnia
• Dizziness

See Also

• Prokinetic agent
• Antipsychotic
• Dopamine D2 receptor

References

Levosulpiride Resources
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