MTF1

MTF1 (Metal Response Element Binding Transcription Factor 1) is a protein that in humans is encoded by the MTF1 gene. This protein is a zinc finger transcription factor that binds to metal response elements (MREs) in the promoters of metal-regulated genes. It is a key regulator of heavy metal homeostasis and detoxification in mammals.

Function

MTF1 is a nuclear protein that binds to the metal regulatory elements (MREs) of a number of genes activated by exposure to heavy metals such as cadmium, zinc, and copper. It is involved in the transcriptional regulation of these genes, and thus plays a crucial role in the cellular response to metal ion stress.

Structure

The MTF1 protein contains six Cys2His2-type zinc finger domains, which allow it to bind to DNA. The zinc fingers are located towards the C-terminus of the protein, while the N-terminus is involved in transcriptional activation.

Clinical Significance

Mutations in the MTF1 gene have been associated with a variety of human diseases, including neurodegenerative diseases and cancer. In particular, overexpression of MTF1 has been observed in several types of cancer, suggesting a potential role in tumorigenesis.

File:MTF1 structure.png

Structure of the MTF1 protein. The zinc fingers are shown in blue.

See Also

• Zinc finger
• Transcription factor
• Heavy metal (chemistry)

References

‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian