Muromonab-CD3
Muromonab-CD3 (trade name Orthoclone OKT3) is a medication used in the prevention and treatment of acute transplant rejection. It is a monoclonal antibody targeted at the CD3 receptor, a membrane protein on the surface of T cells. It was the first monoclonal antibody to be approved for clinical use in humans.
Mechanism of action[edit | edit source]
Muromonab-CD3 works by binding to the CD3 receptor on the surface of T cells. This binding triggers a series of events that ultimately leads to the destruction of the T cell. This reduces the number of T cells available to mount an immune response, thereby reducing the risk of transplant rejection.
Uses[edit | edit source]
Muromonab-CD3 is primarily used in the prevention and treatment of acute transplant rejection. It is often used in combination with other immunosuppressive drugs to enhance its effectiveness.
Side effects[edit | edit source]
Common side effects of muromonab-CD3 include fever, chills, nausea, vomiting, and diarrhea. More serious side effects can include anaphylaxis, a severe allergic reaction that can be life-threatening.
History[edit | edit source]
Muromonab-CD3 was the first monoclonal antibody to be approved for clinical use in humans. It was approved by the FDA in 1986.
See also[edit | edit source]
References[edit | edit source]
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