N-methyltryptamine

N-Methyltryptamine (NMT) is a member of the tryptamine family. It is a naturally occurring alkaloid that is structurally similar to other tryptamines.

Chemistry

N-Methyltryptamine is a derivative of the amino acid tryptophan. It is a mono-methylated tryptamine, structurally similar to other tryptamines such as DMT, DET, and MET. The chemical formula of NMT is C12H16N2.

Biosynthesis

N-Methyltryptamine is biosynthesized via the action of the enzyme tryptamine N-methyltransferase on tryptamine. This reaction is part of the larger biosynthetic pathway for the production of dimethyltryptamine from tryptophan.

Pharmacology

N-Methyltryptamine acts as a serotonin receptor agonist. It has been found to inhibit serotonin reuptake, and thus may act as a serotonin-norepinephrine reuptake inhibitor.

Natural occurrence

N-Methyltryptamine has been found in a variety of plants and animals, including certain species of Acacia, Virola, and Phalaris.

See also

• Tryptamine
• Dimethyltryptamine
• Psychedelic drug

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