NLRP7

NLRP7 (NLR family pyrin domain containing 7) is a protein that in humans is encoded by the NLRP7 gene. It is a member of the NLRP family, which is known for its role in the innate immune response. Mutations in this gene have been associated with recurrent hydatidiform moles and reproductive wastage in humans.

Function

The NLRP7 protein is part of the NLRP family, which is involved in the formation of inflammasomes. These are multiprotein complexes that respond to pathogens and other harmful substances by initiating an inflammatory response. The NLRP7 protein is thought to play a role in this process, although the exact mechanism is not fully understood.

Clinical significance

Mutations in the NLRP7 gene have been associated with recurrent hydatidiform moles (RHM), a type of gestational trophoblastic disease. This condition is characterized by abnormal growth of placental tissue, and can lead to miscarriage or other complications during pregnancy. Women with mutations in the NLRP7 gene are at increased risk of developing RHM.

In addition to RHM, mutations in the NLRP7 gene have also been linked to reproductive wastage, which includes recurrent miscarriage, stillbirth, and infertility. However, more research is needed to fully understand the role of the NLRP7 gene in these conditions.

See also

• NLRP
• Inflammasome
• Hydatidiform mole
• Gestational trophoblastic disease
• Miscarriage
• Stillbirth
• Infertility

References

NLRP7 Resources
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