Nafarelin acetate

Nafarelin Acetate is a synthetic gonadotropin-releasing hormone (GnRH) agonist. It is primarily used in the treatment of endometriosis and central precocious puberty (CPP). Nafarelin acetate is marketed under the brand names Synarel and Synarela.

Pharmacology

Nafarelin acetate works by decreasing the production of certain hormones in the body. It is a GnRH agonist, which means it stimulates the release of gonadotropin hormones from the pituitary gland. These hormones control the release of estrogen and progesterone, which are involved in the menstrual cycle and the growth of endometriosis lesions.

Medical Uses

Nafarelin acetate is used in the treatment of endometriosis, a condition where tissue similar to the lining of the uterus grows outside of the uterus. It is also used to treat central precocious puberty, a condition where puberty starts too early in children.

Side Effects

Common side effects of nafarelin acetate include hot flashes, vaginal dryness, and mood changes. Less common side effects can include bone loss, changes in sexual desire, and changes in body weight.

Contraindications

Nafarelin acetate is contraindicated in patients with hypersensitivity to GnRH or GnRH agonist analogs. It is also contraindicated in women who are pregnant or may become pregnant.

See Also

• Gonadotropin-releasing hormone
• Endometriosis
• Central precocious puberty

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