OR4C3

OR4C3 is a gene that encodes the olfactory receptor, family 4, subfamily C, member 3 in humans. The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Function

The protein encoded by the OR4C3 gene is an olfactory receptor, a type of G protein-coupled receptor that is expressed in the olfactory epithelium of the nose. These receptors are responsible for the detection of odorants, which are then transduced into an electrical signal that is relayed to the brain for processing.

Clinical Significance

While the specific clinical significance of OR4C3 is not yet fully understood, olfactory receptors in general have been implicated in a variety of diseases, including Parkinson's disease, Alzheimer's disease, and certain types of cancer. Further research is needed to determine the specific role of OR4C3 in these and other conditions.

Research

Research into the function and potential clinical applications of OR4C3 is ongoing. Current areas of investigation include the role of olfactory receptors in disease pathogenesis and the potential use of these receptors as therapeutic targets.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Olfactory epithelium

References

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