PCDH1

PCDH1 or Protocadherin-1 is a protein that in humans is encoded by the PCDH1 gene. This gene is a member of the protocadherin family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a chromosome region containing other members of the protocadherin family. The function of this protein is not yet known.

Function[edit | edit source]

Protocadherin-1 is a member of the cadherin superfamily. Cadherins are a type of protein found in the cell membrane and are responsible for cell adhesion. They play a crucial role in maintaining the structure and function of tissues and organs. Protocadherin-1, like other members of the protocadherin family, is thought to play a role in the establishment and function of specific cell-cell connections in the brain.

Clinical significance[edit | edit source]

Mutations in the PCDH1 gene have been associated with asthma susceptibility. Studies have shown that variations in this gene may increase the risk of developing asthma, particularly in people who are exposed to environmental factors such as tobacco smoke.

References[edit | edit source]

External links[edit | edit source]

PCDH1 at the National Center for Biotechnology Information

PCDH1 Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.