Palmitoylethanolamide
Palmitoylethanolamide (PEA) is a naturally occurring fatty acid amide, belonging to the class of nuclear factor agonists. PEA has been demonstrated to bind to a receptor in the cell-nucleus (a nuclear receptor) and exerts a great variety of biological functions related to chronic pain and inflammation. The main target is thought to be the peroxisome proliferator-activated receptor alpha (PPAR-α).
History[edit | edit source]
PEA was identified in the 1950s as a therapeutic principle in egg yolk. In the 1990s, its anti-inflammatory properties were identified. PEA is currently under investigation in clinical trials for its potential therapeutic role in various diseases.
Pharmacology[edit | edit source]
PEA is an endogenous fatty acid amide and belongs to the class of nuclear factor agonists. PEA has been shown to have anti-inflammatory, analgesic, neuroprotective, and anticonvulsant properties.
Clinical significance[edit | edit source]
PEA has been suggested as a potential therapeutic agent in a variety of disorders, including neuropathic pain, neurodegenerative diseases, and inflammation.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD