Primary follicle

Primary Follicle

A Primary Follicle is a stage of ovarian follicle development that follows the primordial follicle stage. It is a crucial part of the ovarian cycle, which is a key component of human reproduction.

Overview[edit | edit source]

The primary follicle is characterized by the presence of a single layer of cuboidal epithelial cells, also known as granulosa cells, surrounding the oocyte. This stage of follicle development is initiated by the activation of primordial follicles, which are dormant structures present in the ovary from birth.

Development[edit | edit source]

The development of a primary follicle from a primordial follicle is triggered by the secretion of Follicle-stimulating hormone (FSH) from the pituitary gland. This hormone stimulates the granulosa cells to proliferate and the oocyte to grow, leading to the formation of a primary follicle.

Function[edit | edit source]

The primary follicle plays a crucial role in oogenesis, the process of female gamete production. The granulosa cells of the primary follicle secrete estrogen, a hormone that is essential for the regulation of the menstrual cycle and the preparation of the uterus for pregnancy.

Clinical Significance[edit | edit source]

Abnormalities in primary follicle development can lead to a variety of reproductive disorders, including polycystic ovary syndrome (PCOS) and premature ovarian failure (POF). These conditions can result in infertility and other health complications.