Quinazolinones

Quinazolinones are a class of organic compounds in the organic chemistry field. They are known as heterocyclic compounds, which are cyclic compounds that contain atoms of at least two different elements as members of its rings. Quinazolinones are used in the synthesis of a variety of pharmaceutical drugs.

Structure

Quinazolinones are characterized by a two-ring structure, one of which is a benzene ring and the other is a pyrimidine ring. The pyrimidine ring contains two nitrogen atoms and four carbon atoms, while the benzene ring contains six carbon atoms.

Synthesis

Quinazolinones can be synthesized through several methods. One common method is the condensation of anthranilic acid with formamide, followed by cyclization. Other methods include the reaction of 2-aminobenzylamine with isocyanates, and the reaction of 2-aminobenzoyl chloride with amines.

Uses

Quinazolinones are used in the synthesis of a variety of pharmaceutical drugs. Some of these drugs include prazosin, doxazosin, and terazosin, which are used to treat high blood pressure and benign prostatic hyperplasia. Other drugs synthesized from quinazolinones include gefitinib and erlotinib, which are used in the treatment of certain types of cancer.

See also

• Benzene
• Pyrimidine
• Anthranilic acid
• Formamide
• Prazosin
• Doxazosin
• Terazosin
• Gefitinib
• Erlotinib

Quinazolinones Resources
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