RACGAP1

Protein RACGAP1 PDB 2ovj

RACGAP1

RACGAP1 is a gene that encodes a protein known as Rac GTPase-activating protein 1. This protein plays a crucial role in regulating cell division and cell migration processes. The RACGAP1 gene is located on chromosome 1 in humans.

Function

The primary function of RACGAP1 is to act as a GTPase-activating protein for the Rho family of small GTPases, particularly Rac1 and Cdc42. By promoting the hydrolysis of GTP to GDP, RACGAP1 helps in the inactivation of these GTPases, leading to the regulation of various cellular processes such as cytoskeletal organization, cell adhesion, and cell motility.

Structure

The RACGAP1 protein consists of several domains, including a RhoGAP domain responsible for its GTPase-activating function. Additionally, it contains a coiled-coil domain that is involved in protein-protein interactions and a PH domain that may be important for membrane localization.

Clinical Significance

Mutations in the RACGAP1 gene have been associated with certain cancers, including breast cancer and colorectal cancer. Dysregulation of RACGAP1 expression has been linked to increased cell proliferation and metastasis in cancer cells.

Interactions

RACGAP1 interacts with various other proteins involved in cell signaling pathways and cytoskeletal dynamics. These interactions play a crucial role in coordinating cellular processes such as cell division and migration.