RBP7

RBP7 or Retinol Binding Protein 7 is a protein that in humans is encoded by the RBP7 gene. It is a member of the lipocalin family and plays a significant role in the transport of retinol (vitamin A) from the liver storage site to peripheral tissues.

Function

RBP7 is a newly identified member of the retinol binding protein (RBP) family. It is known to be highly expressed in the epidermis and is believed to play a role in the cellular uptake and metabolism of retinol, which is crucial for skin homeostasis.

Structure

The RBP7 protein has a molecular weight of approximately 21 kDa and is composed of a single polypeptide chain. It shares a high degree of structural similarity with other members of the RBP family, including a hydrophobic pocket that is responsible for binding retinol.

Clinical Significance

While the exact role of RBP7 in human health and disease is still under investigation, it is believed to play a role in skin health due to its high expression in the epidermis and its involvement in retinol metabolism. Abnormalities in retinol metabolism have been linked to a variety of skin conditions, including psoriasis and acne.

Research

Current research is focused on further elucidating the role of RBP7 in retinol metabolism and skin health, as well as investigating potential therapeutic applications of modulating RBP7 activity.

See Also

• Retinol binding protein
• Retinol
• Lipocalin
• Epidermis

References

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